22 April 2008
Vol 1, Issue 16
  • Contents

    • Editors' Choice

      • Don’t Try This at Home

        Genetic rewiring of transcriptional regulatory networks in bacteria is surprisingly well tolerated.

      • Just When You Thought It Was Pseudo

        The pseudokinase Ca2+/calmodulin-activated serine-threonine kinase (CASK), which was assumed to be catalytically inactive, has kinase activity in vivo.

      • Enhancing the Immune Response

        Aluminum-containing adjuvants stimulate dendritic cells by means of uric acid.

      • Receptor-dsRNA-Receptor

        Two horseshoe-shaped monomers of an innate immunity receptor bind to double-stranded RNA through carboxyl-terminal dimerization, ultimately triggering inflammation.

      • Little Change, Large Consequence

        Flagellar proteins from two bacterial species diverge in their coiled-coil regions; only one triggers an immune response, which may have driven their evolutionary divergence.

      • NADPH Sensor Regulates NO Production

        When NADPH is decreased, HSCARG appears to inhibit argininosuccinate synthetase to limit nitric oxide production.

      • Nuclear Lamin for Gene Silencing

        Silencing of the bam gene in Drosophila involves Decapentaplegic (Dpp) signaling and the nuclear membrane protein Otefin.

      • Autonomous Tracheal Sprouting

        HIF is required for hypoxia-induced tracheal sprouting in Drosophila but not for normal development.

      • The Yin and Yang of Neuronal Maintenance

        Modeling and experiments show that neurons survive during development when neuronal sensitization to survival signals outweighs antagonistic signals for cell death.

      • Thinking Globally, Acting Locally

        Localized regulation of translation may be more widespread than previously thought.

      • Cellular Orienteering

        A developmental signal causes clustering of membrane-associated proteins (including its receptor) at one end of the cell, marking the cell's polarity for directional movement.

      • Putting β-Catenin on the Rac

        During canonical Wnt signaling, nuclear translocation of β-catenin involves a pathway that includes PI3K, Rac1, and JNK2.

About The Cover

COVER This week's issue contains three new entries to ST NetWatch that highlight software and database resources for building and using mathematical models of signaling pathways. BioModels Database is a collection of mathematical models of biological pathways; CellDesigner enables users to build such mathematical models; and researchers can integrate mathematical models and share data between different applications using the Systems Biology Workbench. [Image: Christopher Bickel, AAAS]