PerspectiveBone Formation

Notch Signaling in Osteoblasts

Sci. Signal.  29 Apr 2008:
Vol. 1, Issue 17, pp. pe17
DOI: 10.1126/stke.117pe17

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Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.

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