Cell Biology

Where the PS Is

Science Signaling  15 Jan 2008:
Vol. 1, Issue 2, pp. ec20
DOI: 10.1126/stke.12ec20

The surface charge of the plasma membrane is a crucial determinant of the targeting of signaling proteins. Yeung et al. have developed a probe that can reveal the location of the major negatively charged phospholipid, phosphatidylserine (PS), within cell membranes. PS was found in the cytosolic leaflet of the plasma membrane and on endosomes and lysosomes. It appeared to play a role in the targeting of a variety of positively charged proteins within these membranes.

T. Yeung, G. E. Gilbert, J. Shi, J. Silvius, A. Kapus, S. Grinstein, Membrane phosphatidylserine regulates surface charge and protein localization. Science 319, 210-213 (2008). [Abstract] [Full Text]