Cell Cycle

Regulating the Regulators

Science Signaling  24 Jun 2008:
Vol. 1, Issue 25, pp. ec231
DOI: 10.1126/scisignal.125ec231

Much of the control of cell division comes down to turning on or off the activity of the cyclin-dependent kinases. Seki et al. help clarify how the transition from the G2 phase of the cell cycle into mitosis is controlled in mammalian somatic cells. The depletion of Bora, a protein encoded by a gene actively transcribed at the G2 phase of the cell cycle, prevented activation of another key kinase in cell cycle control, polo-like kinase 1 (Plk1). Bora directly interacted with Plk1, enhancing phosphorylation of Plk1 by yet another kinase that plays a role in cell cycle regulation, Aurora A.

A. Seki, J. A. Coppinger, C.-Y. Jang, J. R. Yates III, G. Fang, Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry. Science 320, 1655-1658 (2008). [Abstract] [Full Text]