Developmental Biology

Developing the Lateral Line

Science Signaling  01 Jul 2008:
Vol. 1, Issue 26, pp. ec242
DOI: 10.1126/scisignal.126ec242

Fish use the lateral line to sense changes in pressure and water movements that may signal the arrival of food or predators. Nechiporuk and Raible now use genetics, cell transplantation, and live imaging to study lateral line development in zebrafish. In zebrafish, the lateral line develops from front to back, with a migrating zone of progenitor cells laying down repeated clusters of hair cells in its wake. Fibroblast growth factor signaling is involved in several aspects of the process--migration, deposition of a primordium, and differentiation.

A. Nechiporuk, D. W. Raible, FGF-dependent mechanosensory organ patterning in zebrafish. Science 320, 1774-1777 (2008). [Abstract] [Full Text]