Vol 1, Issue 27
- Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities
TIMPs can act directly through cell surface receptors or indirectly through modulation of proteases.
Decreased activity of RhoA and destabilization of basal microtubules lead to basement membrane breakdown at the onset of the epithelial-mesenchymal transition during gastrulation.
Nitrosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) leads to its nuclear translocation and the stimulation of nuclear protein acetyltransferases to contribute to apoptosis.
Analysis of known and theoretical oscillatory circuits in cells shows that those with both negative and positive feedback are more robust and allow frequency control independent of amplitude.