Cell Biology

Tumor Suppressor Yin-Yang

Science Signaling  22 Jan 2008:
Vol. 1, Issue 3, pp. ec28
DOI: 10.1126/stke.13ec28

The Wnt signal transduction pathway is a critical player in the development of animals. However, inappropriate activation of this pathway triggers tumorigenesis; for example, disruption of the adenomatous polyposis coli (APC) tumor suppressor, a negative regulator of Wnt signaling, results in colorectal carcinoma development. Although APC is well known to function in inhibiting gene expression, Takacs et al. now report that fruit fly homologs of APC have an opposing job in the activation of Wnt signaling. Separable domains in APC not only restrained inappropriate signaling when the Wnt signal was absent but also promoted signaling upon Wnt stimulation.

C. M. Takacs, J. R. Baird, E. G. Hughes, S. S. Kent, H. Benchabane, R. Paik, Y. Ahmed, Dual positive and negative regulation of Wingless signaling by adenomatous polyposis coli. Science 319, 333-336 (2008). [Abstract] [Full Text]