Editors' ChoicePlant Science

Brassinosteroid Signaling

Science Signaling  29 Jul 2008:
Vol. 1, Issue 30, pp. ec275
DOI: 10.1126/scisignal.130ec275

Brassinosteroids, a type of steroid hormone in plants, regulate a variety of developmental processes. Some genetic targets and signaling components targeted by the brassinosteroids have been identified, but the full chain of command remains unclear. By focusing their attention on proteins in the plasma membrane or proteins modified by phosphorylation, Tang et al. were able to identify two previously unknown kinases (BSK1 and BSK2) that interact with the brassinosteroid receptor at the plasma membrane. BRI1 kinase, the brassinosteroid receptor, phosphorylates these two substrate kinases to activate downstream brassinosteroid signaling.

W. Tang, T.-W. Kim, J. A. Oses-Prieto, Y. Sun, Z. Deng, S. Zhu, R. Wang, A. L. Burlingame, Z.-Y. Wang, BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis. Science 321, 557-560 (2008). [Abstract] [Full Text]