PerspectiveImmunology

A New TRADDition in Intracellular Antiviral Signaling

Science Signaling  29 Jul 2008:
Vol. 1, Issue 30, pp. pe36
DOI: 10.1126/scisignal.130pe36

You are currently viewing the abstract.

View Full Text

Abstract

To effectively defeat viral infection, a mammalian host must detect the presence of viruses and activate a robust antiviral response, which is mediated by cytokines known as type I interferons (IFNs). Much excitement has been generated by the discovery of the retinoic acid–induced gene 1–like helicase (RLH) pathway, which detects RNA-containing viruses in the cytoplasm and activates the type I IFN response. A study now describes a role for the tumor necrosis factor receptor (TNFR)–associated death domain (TRADD) in the antiviral response and sheds new light on how the RLH signaling complex is organized upon viral infection.

View Full Text