New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium–Sensing Receptor

Sci. Signal., 2 September 2008
Vol. 1, Issue 35, p. pe40
DOI: 10.1126/scisignal.135pe40

New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium–Sensing Receptor

  1. Edward M. Brown1 and
  2. Jane B. Lian2,*
  1. 1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 20115, USA.
  2. 2Department of Cell Biology and Orthopedic Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  1. *Corresponding author. E-mail, jane.lian{at}umassmed.edu

Abstract

Experiments performed in mice in which expression of the extracellular calcium–sensing receptor (CaSR) was completely nullified specifically in parathyroid cells, chondrocytes, or cells of the osteoblast lineage have identified phenotypes that indicate a key role for the CaSR in embryonic development of the skeleton, postnatal bone formation, and osteoblast differentiation that are independent of the calcitropic hormone axis. These long-awaited studies further clarify the signaling relationships between the parathyroid gland, kidney, and metabolic bone disease in patients with mutations in the gene encoding the CaSR, and they provide new insights into understanding the signaling pathways involving the CaSR in skeletal cells.

Citation:

E. M. Brown and J. B. Lian, New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium–Sensing Receptor. Sci. Signal. 1, pe40 (2008).

The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion
L. Kantham, S. J. Quinn, O. I. Egbuna, K. Baxi, R. Butters, J. L. Pang, M. R. Pollak, D. Goltzman, and E. M. Brown
Am. J. Physiol. Endocrinol. Metab. 297, E915-E923 (1 October 2009)

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