ReviewCell Biology

Alternative Wnt Signaling Is Initiated by Distinct Receptors

Sci. Signal.  02 Sep 2008:
Vol. 1, Issue 35, pp. re9
DOI: 10.1126/scisignal.135re9

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Abstract

An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.

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