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This conversation is about research highlighted in the Editors' Choice summary titled, “Promoting an Inactivating Partnership.” The highlighted article is G. Hajishengallis, M. Wang, S. Liang, M. Triantafilou, K. Triantafilou, “Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function,” Proc. Natl. Acad. Sci. U.S.A. 105, 13532–13537 (2008).