PerspectiveCell Biology

A Scaffold Makes the Switch

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Sci. Signal.  21 Oct 2008:
Vol. 1, Issue 42, pp. pe46
DOI: 10.1126/scisignal.142pe46

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Abstract

Protein kinase cascades are a reoccurring feature of signal transduction pathways. Recent investigations have focused on how kinase-scaffolding proteins help to convert a graded stimulus into a switch-like or binary response. New findings reveal that the graded-to-binary conversion can be turned on or off, depending on the location of the scaffold within the cell.

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