Probing Pathways Periodically

Sci. Signal., 21 October 2008
Vol. 1, Issue 42, p. pe47
DOI: 10.1126/scisignal.142pe47

Probing Pathways Periodically

  1. Timothy C. Elston*
  1. Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
  1. *Corresponding author. E-mail: telston{at}


Signal transduction pathways are used by cells to process and transmit information about their external surroundings. These systems are dynamic, interconnected molecular networks. Therefore, full characterization of their behavior requires a systems-level analysis. Investigations with temporally oscillating input signals probed the dynamic properties of the high-osmolarity glycerol (HOG) pathway of the budding yeast Saccharomyces cerevisiae. These studies shed light on how the network functions as a whole to respond to changing environmental conditions.


T. C. Elston, Probing Pathways Periodically. Sci. Signal. 1, pe47 (2008).

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