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COVER This week's issue features a Research Article that shows that signaling mediated by the adaptor protein DAP12 is essential for macrophages to fuse and form multinucleated giant cells, which are a hallmark of granulomatous inflammation. The cover shows macrophages that have fused (yellow). [Image: Laura Helming, Technical University of Munich, Germany]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882