Journal ClubHypoxia

The HIF-1α–C/EBPα Axis

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Science Signaling  28 Oct 2008:
Vol. 1, Issue 43, pp. jc2
DOI: 10.1126/scisignal.143jc2

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The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBPα) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1α and C/EBPα interact, they bring about reciprocal functional changes, so that the activity of HIF-1α is decreased and that of C/EBPα is restricted or increased in a tissue-specific manner. This Journal Club article highlights research depicting interactions between HIF-1α and C/EBPα and discusses conditions and tissues in which this interaction might occur.

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