Editors' ChoiceImmunology

TRPM7 and T Cell Development

Science Signaling  04 Nov 2008:
Vol. 1, Issue 44, pp. ec377
DOI: 10.1126/scisignal.144ec377

The transient receptor potential melastatin-like 7 (TRPM7) protein is a membrane ion channel that conducts Ca2+ and Mg2+ ions. Its physiological role has been proposed to be essential for Mg2+ uptake and homeostasis of Mg2+ concentrations in whole animals. To examine the physiological roles of the channel in vivo, Jin et al. studied mice in which the channel was specifically depleted from the T cell lineage. The results suggest that TRPM7 is required for a developmentally important step in thymic maturation of T cells.

J. Jin, B. N. Desai, B. Navarro, A. Donovan, N. C. Andrews, D. E. Clapham, Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322, 756-760 (2008). [Abstract] [Full Text]