Research ArticleGenomic Screening

New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening

Sci. Signal.  11 Nov 2008:
Vol. 1, Issue 45, pp. ra12
DOI: 10.1126/scisignal.2000037

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Finding the Right Candidate

A genome-wide RNAi screen in human colon cancer cells, followed by two additional validation steps, reveals new components of the Wnt pathway. Combining RNAi analysis with protein-protein interaction data provides a powerful approach that not only identifies new players in a signaling pathway, but also provides functional insight about the modulators, leading to the generation of testable hypotheses.

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