PerspectiveTranscriptional Coordination

Bursting into the Nucleus

Science Signaling  23 Dec 2008:
Vol. 1, Issue 51, pp. pe54
DOI: 10.1126/scisignal.151pe54

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An increase in extracellular Ca2+ induces the nuclear localization of the Crz1 transcription factor and the activation of target genes in yeast. A recent study indicates that nuclear entry occurs in short stochastic bursts that are unsynchronized within the population of cells. The frequency but not the amplitude of the bursts is controlled by Ca2+. Modulation of the frequency of the burst coordinates aspects of expression of Crz target genes.

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