Structure and Function of the Phosphothreonine-Specific FHA Domain

Science Signaling  23 Dec 2008:
Vol. 1, Issue 51, pp. re12
DOI: 10.1126/scisignal.151re12

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  1. Article
    1. Abstract
    2. Introduction
    3. Structures of Free FHA Domains
    4. Combinatorial Library Approach and Ligand Specificity
    5. Diversity of FHA-Ligand Interactions Based on Biological Approaches
    6. FHA Domains with pThr+3 Specificities
    7. FHA Domains That Recognize Residues Both N-Terminal and C-Terminal to pThr
    8. Dun1-FHA Contains Two pThr Sites
    9. Ki67-FHA Recognizes an Extended Binding Surface
    10. FHA Domains Mostly Use Loops for Ligand Binding and Specificity Control
    11. Biological Functions of FHA Domains
    12. Checkpoint Signaling in Humans: Chk2, RNF8, NBS1, and MDC1
    13. PNK and ATPX in the Regulation of DNA Repair Pathways
    14. Cds1, Rad53, and Dun1 in Checkpoint Signaling in Yeast
    15. Roles for KAPP and DDL in Growth and Development in Plants
    16. Role for EmbR in Bacterial Regulatory Pathways
    17. Future Perspectives
    18. Acknowledgments
    19. References and Notes
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