Structure and Function of the Phosphothreonine-Specific FHA Domain

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Sci. Signal.  23 Dec 2008:
Vol. 1, Issue 51, pp. re12
DOI: 10.1126/scisignal.151re12

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The forkhead-associated (FHA) domain is a signaling domain present in various proteins from prokaryotes and eukaryotes. It interacts with other proteins on the basis of its ability to specifically recognize phosphothreonine residues. Proteins that contain the FHA domain play important functional roles in such processes as protein kinase signaling, cell cycle regulation, and DNA damage response. It is now evident that interference with the binding capabilities of these domains can elicit abnormal cellular responses. Detailed structural analyses have led to an understanding of the structural bases of the biological functions of the FHA domain. Information about this structure-function relationship will be useful in understanding the signaling mechanisms that involve FHA domains and, potentially, in the design of therapeutics.