Quantitative Models of Mammalian Cell Signaling Pathways

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Science Signaling  19 Feb 2008:
Vol. 1, Issue 7, pp. tr1
DOI: 10.1126/stke.17tr1

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This teaching resource provides lecture notes and slides for a class on mathematical modeling of mammalian signaling pathways. This lecture was part of the course "Cell Signaling Systems: A Course for Graduate Students" and focused on quantitative modeling. The lecture describes how different types of mathematical representations are applied to different signaling systems to provide insight into how a signaling system controls cell behavior. The development of an ordinary differential equation–based model for a bistable switch and the predictions that can be obtained from the model are described. The lecture concludes with a description of how models can be tested experimentally and modified when the details of the models and the resultant predictive behavior are not confirmed by experimentation.

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