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COVER This week's issue features a Perspective on how the presence of the Wnt antagonist Dickkopf1 (Dkk1) determines whether Kremens proteins will either inhibit or stimulate Wnt signaling. The image shows Kremen (in green) with Dkk1 (in blue) internalizing the Wnt co-receptor LRP6 (in red), thus dissociating LRP6 from the Wnt receptor Frizzled at the plasma membrane. [Image: Christopher Bickel, AAAS]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882