A Cytoskeletal Platform for Local Translation in Axons

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Sci. Signal.  26 Feb 2008:
Vol. 1, Issue 8, pp. pe11
DOI: 10.1126/stke.18pe11

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Recent data indicate that local translation in growth cones is critical for axon guidance. Evidence from the Drosophila midline axon guidance system suggests that the F-actin-microtubule cross-linker Short stop (Shot) might link the translation machinery to the cytoskeleton in the growth cone. The identification of a complex of translation factors attached to the actin and microtubule networks points to a mechanism by which cytoskeletal dynamics regulate translation in axons and vice versa.

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