Vol 10, Issue 460
- The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis
The targeting of Lipin1 by the SCFβ-TRCP E3 ubiquitin ligase complex enhances lipid synthesis and accumulation in the liver.
- The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection
The tyrosine kinase Src couples activation of multiple pattern recognition receptors to the production of type I interferon.
This week’s articles highlight advances in treating spinobulbar muscular dystrophy by activating adenylyl cyclase and autoimmune disease by inhibiting protein interactions that mediate T cell signaling.
This week’s articles highlight the development of hair and sweat glands in human skin, how calcium signals affect the sensitivity of a mouse’s whiskers, peptide hormone processing in plants, and conformational changes that enable bacteriorhodopsin to harvest energy from light.
This week’s articles highlight a way to enhance crop yield by manipulating sugar signaling, how blood flow patterns affect mechanical signaling in endothelial cells, how an innate immune sensor blocks PI3K signaling in the gut, and structural insights into cannabinoid receptors.
Metformin reduces cellular ATP and restricts passive transport through the nuclear pore to limit nuclear activation of a protein that activates mTORC1.