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Papers of note in Science Translational Medicine 8 (370)

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Sci. Signal.  03 Jan 2017:
Vol. 10, Issue 460, eaam6507
DOI: 10.1126/scisignal.aam6507

This week’s articles highlight advances in treating spinobulbar muscular dystrophy by activating adenylyl cyclase and autoimmune disease by inhibiting protein interactions that mediate T cell signaling.

NEURODEGENERATIVE DISEASE

Purging X-tra protein aggregates

Adenylyl cyclase activating polypeptide modifies androgen receptor phosphorylation and spinal and bulbar muscular atrophy pathogenesis.

AUTOIMMUNITY

Toning down T cell signaling to treat autoimmunity

A novel inhibitor of interactions between signaling proteins in T cells demonstrates promising preventive and therapeutic effects in several models of autoimmune disease.

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