Editors' ChoiceCell Metabolism

Placing the nuclear pore in the metformin mechanism of action

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Sci. Signal.  03 Jan 2017:
Vol. 10, Issue 460, eaam6836
DOI: 10.1126/scisignal.aam6836

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Metformin reduces cellular ATP and restricts passive transport through the nuclear pore to limit nuclear activation of a protein that activates mTORC1.

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