Vol 10, Issue 461
- Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer
E6AP exhibits tumor suppressor activity that may help stratify NSCLC patients.
- Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice
The voltage-gated Na+ channel Nav1.7 controls the balance of pain-promoting and pain-relieving receptor input.
- Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli
A single stimulus triggers cross talk between two signaling systems that promotes antibiotic resistance in uropathogenic Escherichia coli.
This week’s articles show that targeting the receptor PAR4 may be a safe antiplatelet agent and that a live cell–based therapy stimulates wound healing in leg ulcers.
This week’s articles show how targeting a fatty acid receptor blocks metastasis, reveal the structural basis for the mechanism of action of a potassium channel, and indicate that splicing factor 1 is required for life span extension in worms.