Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine 9 (371)

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Sci. Signal.  10 Jan 2017:
Vol. 10, Issue 461, eaam7188
DOI: 10.1126/scisignal.aam7188

This week’s articles show that targeting the receptor PAR4 may be a safe antiplatelet agent and that a live cell–based therapy stimulates wound healing in leg ulcers.

WOUND HEALING

Activating healing in chronic wounds

Stone et al. show that a bioengineered bilayered living cellular construct promotes ulcer healing by modulating inflammation, stimulating wound edge keratinocytes, and attenuating Wnt/β-catenin signaling to activate an acute wound response.

COAGULATION

This antiplatelet agent is just right

Wong et al. report that PAR4 inhibition with a reversible small-molecule antagonist is a promising antiplatelet therapy.

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