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Papers of note in Science Translational Medicine 9 (372)

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Sci. Signal.  17 Jan 2017:
Vol. 10, Issue 462, eaam7597
DOI: 10.1126/scisignal.aam7597

This week’s papers describe new therapeutic avenues to kill tumor-initiating cells in breast, ovarian, and lung cancer patients; mitigate graft-versus-host disease after hematopoietic cell transplants in leukemia patients; and stimulate bone healing in diabetic patients.

TRANSPLANTATION

Guiding T cells to stem GVHD

Betts et al. show that inhibiting Aurora kinase A and JAK2 signal transduction pathways permits the differentiation of potent regulatory T cells while neutralizing alloreactive T cells and preventing graft-versus-host disease without impairing antitumor responses.

BONE REPAIR

Stem cells: The key to boosting bone healing in diabetes

Tevlin et al. show that local delivery of a missing growth factor to the skeletal stem cell niche restores bone healing in diabetic mice.

CANCER

Initiating an antitumor attack

Damelin et al. report that PTK7 is a tumor-initiating cell antigen, which can be targeted with an antibody-drug conjugate to confer sustained tumor regressions.

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