Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 541 (7637)

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Sci. Signal.  24 Jan 2017:
Vol. 10, Issue 463, eaam8098
DOI: 10.1126/scisignal.aam8098

This week’s articles show how a phospholipase both facilitates viral entry and protects the viral genome from degradation, how tumors induce autophagy in their microenvironment to provide nutrients for tumor growth, and how lipids regulate the associations of proteins with membranes.

HOST-PATHOGEN INTERACTIONS

Phospholipase roles in viral infection

Staring et al. (see commentary by McKnight and Lemon) show that the small phospholipase PLA2G16 faciliates delivery of picornavirus genomes into the cytoplasm and prevents their clearance by autophagy.

CANCER

Tumor-induced authophagy fuels growth

Katheder et al. show in Drosophila that tumors induce autophagy in the tumor microenvironment to provide nutrients that facilitate tumor growth.

CELL BIOLOGY

Regulating protein-membrane interactions

Gupta et al. developed a mass spectrometry approach to study how interfacial lipids regulate interactions between membranes and proteins, including G protein–coupled reeptors.

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