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Papers of note in Science Translational Medicine 9 (374)

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Sci. Signal.  31 Jan 2017:
Vol. 10, Issue 464, eaam8627
DOI: 10.1126/scisignal.aam8627

This week’s papers describe therapies for myeloid cancers and a kinase to inhibit in order to prevent pathogenic bone destruction.

BONE DEGENERATION

A new way to resorb bone

Andrade et al. report that inhibition of RON kinase prevents pathogenic bone destruction in mouse models and a human clinical study.

CANCER

Stemming the tide of leukemia development

Chung et al. show that CD99 is a potential therapeutic target enriched on disease stem cells in myeloid malignancies.

CAR sharing

Qasim et al. report that universal gene-edited CAR19 T cells eliminate infant leukemia.

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