Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 541 (7638)

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Sci. Signal.  31 Jan 2017:
Vol. 10, Issue 464, eaam8650
DOI: 10.1126/scisignal.aam8650

This week’s articles are about peptides that mediate communication between viruses, how microglia induce reactive astrocytes that contribute to neuronal cell death, and how kinases of the Hippo pathway influence breast cell fate.

MICROBIOLOGY

Communication between viruses

Erez et al. identified virus-encoded peptides that are secreted by infected cells and mediate communication between viruses (see commentary by Davidson).

NEUROSCIENCE

Inducing neurotoxic reactive astrocytes

Liddelow et al. found that cytokines secreted by microglia induce a subtype of reactive astrocytes that contribute to the death of neurons in mice and are associated with neurodegenerative disorders in humans.

DEVELOPMENTAL BIOLOGY

Hippo pathway kinases and breast cell fate

Britschgi et al. report that kinases of the Hippo pathway influence breast cell fate by promoting the degradation of estrogen receptor-α.

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