Vol 10, Issue 465
- Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms
Inhibition of prostaglandin E2 signaling in macrophages may be a pharmacological option for treating intracranial aneurysms.
- A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation
Transcriptional cofactors that participate in Wnt/β-catenin signaling act in the cytoplasm to promote proper development of tooth enamel.
This week’s articles describe how cellular metabolism contributes to the development of lymphatic vessels, a proinflammatory cytokine that acts as a neuromodulator, how mechanical force frees a growth factor from its protein cage, and the gating mechanism of a cyclic nucleotide–gated ion channel.
This week’s articles show how excitatory synapses are weakened during sleep and how the catalytic subunit of PKC-cs may mediate the choice between different modes of double-strand DNA break repair.