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Papers of note in Science Translational Medicine 9 (375)

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Sci. Signal.  07 Feb 2017:
Vol. 10, Issue 465, eaam9077
DOI: 10.1126/scisignal.aam9077

This week’s articles describe ways to treat arthritis caused by chikungunya virus, IDH-mutant cancers, and hypertension.

INFECTIOUS DISEASE

Taming T cells to ameliorate chikungunya arthritis

Teo et al. report that fingolimod (FTY720) prevents the accumulation of CD4+ T cells in the joints, thus blocking chikungunya virus–induced joint pathology.

Miner et al. show that combination therapy with CTLA4-Ig and an antiviral human monoclonal antibody controls chikungunya virus arthritis in mice.

CANCER

Metabolite as cancer’s Achilles’ heel

Sulkowski et al. discover that the oncometabolite 2-hydroxyglutarate renders IDH1/2 mutant cancer cells deficient in homologous recombination and confers vulnerability to synthetic lethal targeting with PARP inhibitors.

HYPERTENSION

Targeting platelets to control high blood pressure

Kossmann et al. identify a coagulation-inflammation circuit that promotes vascular dysfunction, revealing that factor XI–targeted anticoagulants may be useful for treating hypertension.

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