Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 542 (7639)

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Sci. Signal.  07 Feb 2017:
Vol. 10, Issue 465, eaam9085
DOI: 10.1126/scisignal.aam9085

This week’s articles describe how cellular metabolism contributes to the development of lymphatic vessels, a proinflammatory cytokine that acts as a neuromodulator, how mechanical force frees a growth factor from its protein cage, and the gating mechanism of a cyclic nucleotide–gated ion channel.

DEVELOPMENT

Metabolic control of lymphatic development

Wong et al. found that a rate-controlling enzyme in fatty acid β-oxidation affected epigenetic control of genes required for lymphangiogenesis.

NEUROSCIENCE

Cytokine as neuromodulator

Chen et al. report that the proinflammatory cytokine IL-17 acts on neurons to affect sensory responses in Caenorhabditis elegans.

BIOCHEMISTRY

How mechanical force frees TGF-β

Dong et al. show how binding of an integrin to pro–TGF-β1 allows the growth factor to be released when mechanical force is applied through the integrin (see also Ha).

Gating mechanism explained

Li et al. solved the structure of a cyclic nucleotide–gated ion channel and offer an explanation for how intracellular cycle nucleotides—not voltage—gate these channels.

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