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Papers of note in Science Translational Medicine 9 (376)

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Sci. Signal.  14 Feb 2017:
Vol. 10, Issue 466, eaam9533
DOI: 10.1126/scisignal.aam9533

This week’s articles describe a free radical scavenger for treating hypertension; an engineered bacterium as a cancer immunotherapy; commensal bacteria that protect newborn mice from pneumonia; and a form of gastrointestinal E. coli that triggers proinflammatory systemic inflammation, arthritis, and colitis.

CARDIOVASCULAR DISEASE

A radical idea for blood pressure control

Hilgers et al. report that injection of thioredoxin, a scavenger of free radicals, reversed hypertension in aged mice by decreasing arterial stiffness and increasing nitric oxide synthesis.

CANCER

Two bacteria can be better than one

Zheng et al. show that a Salmonella engineered to secrete flagellin B from another bacterium induced TLR4-dependent antitumor immune cell activity in mice.

HOST-MICROBE INTERACTIONS

Bacteria protect newborn mice from pneumonia

Gray et al. find that exposure of neonatal mice to commensal bacteria immediately after birth promotes the recruitment of group 3 innate lymphoid cells (ILC3) to the lungs to defend against bacterial pneumonia.

Pathosymbiont perturbation of immune homeostasis

Viladomiu et al. discover that IgA-reactive E. coli caused TH17 cell–mediated systemic inflammation, arthritis, and colitis in mouse models of Crohn’s disease.

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