Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 542 (7640)

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Sci. Signal.  14 Feb 2017:
Vol. 10, Issue 466, eaam9617
DOI: 10.1126/scisignal.aam9617

This week’s articles show how intestinal immune cell populations are controlled and how epithelial cells recognize oncogenic neighbors.

IMMUNOLOGY

Controlling intestinal AHR signaling

Schiering et al. show that the metabolism of aryl hydrocarbon receptor ligands by P4501 enzymes reduces the numbers of intestinal immune cells in mice, increasing susceptibility to infection.

CANCER

Recognizing oncogenic cells

Yamamoto et al. show that oncogenic epithelial cells that lose polarity in Drosophila are recognized by neighboring cells and become susceptible to JNK-dependent apoptotic signals.

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