Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 355 (6326)

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Sci. Signal.  21 Feb 2017:
Vol. 10, Issue 467, eaam9937
DOI: 10.1126/scisignal.aam9937

This week’s articles identify a requirement for lipid transport between the endoplasmic reticulum and plasma membrane in insulin release, a mechanism in which contact with a host cell reprograms bacterial gene expression, a signal from a soybean pathogen that impairs soybean’s defense response, and a mechanism by which hair follicles may be leveraged to reduce scar formation.

CELL BIOLOGY

Understanding insulin release

Lees et al. demonstrate that direct lipid transport between the endoplasmic reticulum and the plasma membrane helps to control insulin secretion.

HOST-PATHOGEN INTERACTIONS

Touchdown for gut pathogen virulence

Katsowich et al. report that physical contact with a host cell triggers derepression of virulence effectors and shifts metabolism in a pathogenic form of Escherichia coli.

Host-pathogen point-counterpoint

Ma et al. found that a soybean pathogen releases an extracellular protein that can neutralize plant defenses.

REGENERATION

Hair follicles: Secret to prevent scars?

Plikus et al. showed that hair follicles convert wound myofibroblasts to adipocytes through the bone morphogenetic protein signaling pathway, revealing a target to decrease scarring (see also Chen and Longaker).

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