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Papers of note in Science Translational Medicine 9 (377)

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Sci. Signal.  21 Feb 2017:
Vol. 10, Issue 467, eaam9940
DOI: 10.1126/scisignal.aam9940

This week’s articles report an integrated cell-based assay to test cardiac toxicity of anticancer drugs and discover a pathogen recognized by autoimmune antibodies involved in a form of epilepsy.

TOXICITY SCREENING

Failing fast for tyrosine kinase inhibitors

Sharma et al. measured cell death, contraction, excitability, calcium dynamics, and signal transduction in human induced pluripotent stem cell–derived cardiomyocytes and integrated the results to reveal a “cardiac safety index” for anticancer drugs.

EPILEPSY

Linking parasitic infection to autoimmune epilepsy

Johnson et al. report that patients with epileptic nodding syndrome have autoantibodies to neuronal leiomodin-1 that crossreact with proteins from the parasitic worm Onchocerca volvulus upon infection.

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