Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 355 (6327)

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Sci. Signal.  28 Feb 2017:
Vol. 10, Issue 468, eaan0468
DOI: 10.1126/scisignal.aan0468

This week’s articles describe a method for engineering kinases so that they can be activated and inactivated with visible light and offer a molecular explanation for why mutations that are common in the blood cells of elderly people can promote atherosclerosis.

PROTEIN ENGINEERING

Shining a light on cell signaling

Zhou et al. engineered single-chain photoswitchable kinases that enable fine control of kinase activity.

VASCULAR BIOLOGY

Faulty blood cells and heart disease

Fuster et al. found that bone marrow deficient in a gene that is frequently mutated in blood cells of elderly humans promotes atherosclerosis in mice (see the Perspective by Zhu et al.).

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