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Papers of note in Science Translational Medicine 9 (378)

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Sci. Signal.  28 Feb 2017:
Vol. 10, Issue 468, eaan0469
DOI: 10.1126/scisignal.aan0469

This week’s articles describe a way to limit colonization of the skin by Staphylococcus aureus, a potential therapy for bladder cancer patients, and that autoimmunity associated with type 1 diabetes may begin in infancy.

MICROBIOME

Bacterial biological warfare in atopic dermatitis

Nakatsuji et al. discover that some commensal skin Staphylococcus strains produce antimicrobial peptides that can inhibit colonization of Staphylococcus aureus, which aggravates atopic dermatitis.

CANCER

Cancer’s loss is targeted therapy’s gain

Ler et al. find that bladder cancer cells with loss of the histone demethylase KDM6A are vulnerable to EZH2 inhibitors.

AUTOIMMUNITY

Baby β cells in danger

Heninger et al. report that susceptibility to type 1 diabetes may start in infancy due to the presence of an autoantigen-responsive CD4+ T cell population.

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