Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 542 (7642)

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Sci. Signal.  28 Feb 2017:
Vol. 10, Issue 468, eaan0507
DOI: 10.1126/scisignal.aan0507

This week’s articles demonstrate that fat cells release miRNAs that act on distant tissues, identify a mechanism whereby transcription factors protect B cells from malignant transformation, and show that some anticancer drugs may have the unintended consequence of increasing genomic instability in B cells.

PHYSIOLOGY

miRNAs as adipokines

Thomou et al. found that adipocytes release exosomes containing microRNAs that regulate gene expression in distant tissues.

CANCER

Tumor-suppresive B cell transcription factors

Chan et al. report that two transcription factors protect B cells from malignant transformation by reducing glucose transport.

Unintended consequences of blocking PI3Kδ

Compagno et al. demonstrate that drugs that block PI3Kδ promote genomic instability in B cells (see also Fruman and O’Brien).

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