Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 543 (7643)

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Sci. Signal.  07 Mar 2017:
Vol. 10, Issue 469, eaan0851
DOI: 10.1126/scisignal.aan0851

This week’s articles describe a cause of chronic inflammation in Gaucher disease, a method for improving the efficacy of T cell–mediated cancer immunotherapy, a type of oncogene amplification that enhances tumor heterogeneity, and a mechanism whereby mechanical stress maintains epithelial homeostasis.

IMMUNOLOGY

Fueling the cycle of chronic inflammation

Pandey et al. show that glucosylceramide accumulation in patients with Gaucher disease causes chronic inflammation through the complement cascade.

CANCER

Improving cancer immunotherapy

Eyquem et al. improved the antitumor activity of T cells by expressing a chimeric antigen receptor from an endogenous T cell receptor locus (see also Maus).

Extrachromosomal oncogene amplification

Turner et al. found that extrachromosomal amplification of oncogenes promotes tumor heterogeneity more than does chromosomal amplification.

MECHANOSENSITIVE CHANNELS

Epithelial cells use the force

Gudipaty et al. report that the mechanical strain caused by an epithelium having too few or too many cells induces compensatory changes in cell proliferation or extrusion through the mechanosensitive channel Piezo1 (see also Heisenberg).

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