You are currently viewing the editor's summary.View Full Text
PSMA is more than a diagnostic marker
Detection of prostate-specific membrane antigen (PSMA) diagnoses aggressive prostate cancer and predicts poor prognosis in patients. Using mouse models and tumor cell cultures, Caromile et al. found that the presence of PSMA on the surface of prostate tumor cells directs proliferative signaling through one pathway over another by disrupting the interaction of a receptor tyrosine kinase complex with an intracellular scaffolding protein. The findings suggest that patients with PSMA-positive tumors may benefit from PI3K-AKT pathway inhibitors and reveal a tumorigenic role for this traditionally diagnostic marker.