Research ArticleCancer

PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer

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Sci. Signal.  14 Mar 2017:
Vol. 10, Issue 470, eaag3326
DOI: 10.1126/scisignal.aag3326

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PSMA is more than a diagnostic marker

Detection of prostate-specific membrane antigen (PSMA) diagnoses aggressive prostate cancer and predicts poor prognosis in patients. Using mouse models and tumor cell cultures, Caromile et al. found that the presence of PSMA on the surface of prostate tumor cells directs proliferative signaling through one pathway over another by disrupting the interaction of a receptor tyrosine kinase complex with an intracellular scaffolding protein. The findings suggest that patients with PSMA-positive tumors may benefit from PI3K-AKT pathway inhibitors and reveal a tumorigenic role for this traditionally diagnostic marker.