Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

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Sci. Signal.  14 Mar 2017:
Vol. 10, Issue 470, eaal2323
DOI: 10.1126/scisignal.aal2323

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Glioblastoma (GBM) is the most common and aggressive brain tumor. Standard care combines surgery, radiotherapy, and chemotherapy, but patient median survival does not exceed 15 months. The unfolded protein response (UPR) is an adaptive cellular signaling pathway that promotes restoration of endoplasmic reticulum proteostasis. The UPR plays instrumental roles in various cancers, particularly growth, invasion, therapeutic resistance, and angiogenesis in GBM. In this Review, which contains four figures, two tables, and 219 references, we discuss how adjuvant or neoadjuvant UPR-targeted compounds could impede GBM growth and increase the efficacy of current treatments.

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