Editors' ChoiceMOLECULAR AND CELLULAR SIGNALING

Papers of note in Nature 543 (7644)

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Sci. Signal.  14 Mar 2017:
Vol. 10, Issue 470, eaan1406
DOI: 10.1126/scisignal.aan1406

This week’s articles highlight the role of autophagy in maintaining stem cells and a new player in the repair of double-strand DNA breaks.

STEM CELLS

How autophagy promotes stemness

Ho et al. found that autophagy maintains the stemness and quiescence of hematopoietic stem cells by ridding the cells of active mitochondria.

DNA REPAIR

A new partner for the DNA repair protein 53BP1

Drané et al. identified a protein that prevents the double-strand break repair protein 53BP1 from binding to DNA until damage is detected.

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