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Papers of note in Science Translational Medicine 9 (380)

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Sci. Signal.  14 Mar 2017:
Vol. 10, Issue 470, eaan1407
DOI: 10.1126/scisignal.aan1407

This week’s articles describe an antibody that inhibits two pathways that drive lung cancer and a new way to lessen colitis in Crohn’s disease.

CANCER

Two targets for a bigger punch

Hu et al. generated a customized, dual-targeted antibody that can simultaneously inhibit both the EGFR and Notch pathways to overcome drug resistance in non–small cell lung cancer.

MICROBIOTA

Fungi and inflammatory bowel disease

Chiaro et al. discovered that blocking purine metabolism in gut Saccharomyces cerevisiae may reverse colitis in patients with Crohn’s disease.

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