Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 543 (7645)

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Sci. Signal.  21 Mar 2017:
Vol. 10, Issue 471, eaan2406
DOI: 10.1126/scisignal.aan2406

This week’s articles highlight a function for disordered protein domains, how fish sense electric fields, the subcellular localization of nutrient sensing, metabolism in intestinal stem cells, the bone as an endocrine organ, signaling pathways that are dysregulated in cervical cancer, and a drug that stimulates the recruitment of antitumor macrophages.

BIOCHEMISTRY

Building switches with disordered protein domains

Berlow et al. found that interactions between intrinsically disordered domains mediate a negative feedback mechanism for attenuating the hypoxic response (see also Chong and Forman-Kay).

ION CHANNELS

Molecular basis for electroreception

Bellono et al. reveal that the ability of skates to detect electric fields relies on functional coupling of specific ion channels.

CELL BIOLOGY

Recruiting mTORC1 to the lysosome

Peng et al. and Wolfson et al. describe a lysosomal multiprotein complex that is required for nutrient sensing by mTORC1.

STEM CELLS

Maintenance of stem cell metabolism

Rodríguez-Colman et al. found that intestinal stem cell function depends on high mitochondrial activity, which is supported by lactate released from adjacent, terminally differentiated cells.

PHYSIOLOGY

Bone controls appetite

Mosialou et al. report that LCN2 is a bone-derived hormone that controls appetite and affects glucose homeostasis (see also Palmiter).

CANCER

Integrating genomics and proteomics in cervical cancer

The Cancer Genome Atlas Research Network combined genomic and proteomic analyses to identify signaling pathways that are dysregulated in cervical cancers.

Stimulating antitumor macrophages

Guerriero et al. demonstrated that an HDAC inhibitor reduced tumor burden and metastasis in mice by stimulating the recruitment of macrophages to tumors.

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