Editors' ChoiceCancer Immunology

Paper of note in Science Translational Medicine 9 (381)

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Sci. Signal.  21 Mar 2017:
Vol. 10, Issue 471, eaan2470
DOI: 10.1126/scisignal.aan2470

This week’s article describes a therapy that may enable macrophages to recognize and kill tumor cells in pediatric patients with brain cancer.

CANCER

Brain tumors, meet macrophages

Gholamin et al. show that an engineered antibody against CD47 blocks a “don’t eat me” signal on pediatric brain tumor cells to enable macrophages to attack the tumor in mouse models.

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